Risk of metachronous colon cancer following surgery for rectal cancer in mismatch repair gene mutation carriers

AK Win; S Parry; B Parry; MF Kalady; FA Macrae; DJ Ahnen; GP Young; L Lipton; I Winship; A Boussioutas; JP Young; DD Buchanan; J Arnold; L Le Marchand; PA Newcomb; RW Haile; NM Lindor; S Gallinger; JL Hopper; MA Jenkins

Journal article

Risk of metachronous colon cancer following surgery for rectal cancer in mismatch repair gene mutation carriers

AK Win, S Parry, B Parry, MF Kalady, FA Macrae, DJ Ahnen, GP Young, L Lipton, I Winship, A Boussioutas, JP Young, DD Buchanan, J Arnold, L Le Marchand, PA Newcomb, RW Haile, NM Lindor, S Gallinger, JL Hopper, MA Jenkins

Annals of Surgical Oncology | SPRINGER | Published : 2013

DOI: 10.1245/s10434-012-2858-5

Abstract

Background: Despite regular surveillance colonoscopy, the metachronous colorectal cancer risk for mismatch repair (MMR) gene mutation carriers after segmental resection for colon cancer is high and total or subtotal colectomy is the preferred option. However, if the index cancer is in the rectum, management decisions are complicated by considerations of impaired bowel function. We aimed to estimate the risk of metachronous colon cancer for MMR gene mutation carriers who underwent a proctectomy for index rectal cancer. Methods: This retrospective cohort study comprised 79 carriers of germline mutation in a MMR gene (18 MLH1, 55 MSH2, 4 MSH6, and 2 PMS2) from the Colon Cancer Family Registry w..

View full abstract

University of Melbourne Researchers

Aung Ko Win Author

Finlay Macrae Author

Ingrid Winship Author

Alex Boussioutas Author

Related Projects (1)

COMPREHENISVE MODEL FOR COLORECTAL CANCER RISK

I am a genetic epidemiologist focused on bowel cancer risk. I will develop a comprehensive model to estimate individual cancer risk by study..

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This work was supported by the National Cancer Institute, National Institutes of Health under RFA #CA-95-011 and through cooperative agreements with members of the Colon Cancer Family Registry and Principal Investigators. Collaborating centers include Australasian Colorectal Cancer Family Registry (U01 CA097735), Familial Colorectal Neoplasia Collaborative Group (U01 CA074799) [USC], Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (U01 CA074800), Ontario Registry for Studies of Familial Colorectal Cancer (U01 CA074783), Seattle Colorectal Cancer Family Registry (U01 CA074794), and University of Hawaii Colorectal Cancer Family Registry (U01 CA074806). AKW is supported by the Picchi Brothers Foundation Cancer Council Victoria Cancer Research Scholarship, Australia. MAJ is a Senior Research Fellow and JLH is an Australia Fellow of the National Health and Medical Research Council, Australia.